Search results for " near infrared light"
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Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
Alzheimer’s Disease (AD) is a multifactorial neurodegenerative dementia with no curative therapeutic options. One of the earliest impairments in AD triggering cognitive decline is the synaptic dysfunction induced by the selective targeting and interruption of the synaptic region by the small oligomeric form of amyloid beta (Aβ). Recently, the co-presence of Aβ oligomers (Aβo) and tau oligomers (tau-o) at the synapses has been suggested to exacerbate this dysfunction. Therefore, the development of therapeutics aimed at protecting the synapses from the toxic binding of both proteins at the synapses can preserve synaptic health and cognitive function. With this goal in mind, the present study …
Modulation of hippocampal neurogenesis by Nano-Pulsed Laser Therapy
Neurogenesis is a physiological process through which new neurons are generated and it occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. Specifically, neurogenesis take place thanks to the presence of neuronal stem cells (NSCs) located in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus of the hippocampus. Data present in the literature demonstrate that neurogenesis in the hippocampus decreases during aging and it is impaired in neurodegenerative diseases, such as Alzheimer’s disease, and after traumatic brain injury (TBI). Traumatic Brain Injury (TBI) is a chronic disease that oc…